MW 467.5 Da, Purity >99%. Highly potent, cell-permeable inhibitor of protein kinases such as PKA, PKC, PKG (IC₅₀ = 18-25 nM), Serine/threonine protein kinases (IC₅₀ values are 10-20 nM) and CAM kinase II (Ki = 1.8 nM). Analog of staurosporine (ab120056), exhibits a wide range of effects including neuroprotection and improvement of psoriasis in vivo.
The product is subject to the following: Abcam Restricted Use Statement